Structure of PDB 8owa Chain A

Receptor sequence

>8owaA (length=981) Species: 9986 (Oryctolagus cuniculus)

MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW
ELVIEQFEDLLVRILLLAACISFVLAWFETITAFVEPFVILLILIANAIV
GVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVA
VGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDK
KNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLD
EFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAVALAV
AAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTG
TLTTNQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRS
GQFDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNV
FNTEVRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAVGN
KMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIKEWGTGRDTLR
CLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGMLDPPRKEVMGS
IQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDD
LPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPA
LKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQF
IRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFN
PPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFMYAE
DGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMALSVLVTIEMC
NALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLK
ALDLTQWLMVLKISLPVIGLDEILKFIARNY

3D structure

• PDB: 8owa Photoswitchable inhibitors of the sarco(endo)plasmic calcium pump
• Chain: A
• Resolution: 2.85 Å

Enzymatic activity

• Enzyme Commision number: 7.2.2.10: P-type Ca(2+) transporter.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	VUK	A	L249 L253 F256 V263 I315 I765 V772 I829 F834 Y837 M838	L245 L249 F252 V259 I311 I755 V762 I819 F824 Y827 M828

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0005215 transporter activity
• GO:0005388 P-type calcium transporter activity
• GO:0005509 calcium ion binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006816 calcium ion transport
• GO:0006874 intracellular calcium ion homeostasis
• GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
• GO:0070588 calcium ion transmembrane transport
• GO:0106134 positive regulation of cardiac muscle cell contraction
• GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
• GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
• GO:1990036 calcium ion import into sarcoplasmic reticulum

Cellular Component

• GO:0016020 membrane
• GO:0016529 sarcoplasmic reticulum
• GO:0033017 sarcoplasmic reticulum membrane

External links

• PDB: RCSB:8owa, PDBe:8owa, PDBj:8owa
• PDBsum: 8owa
• UniProt: P04191|AT2A1_RABIT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Gene Name=ATP2A1)