Structure of PDB 8ovw Chain A

Receptor sequence
>8ovwA (length=101) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KQRKDSHKEVERRRRENINTAINVLSDLLPVRESSKAAILACAAEYIQKL
KETDEANIEKWTLQKLLSEQNASQLASANEKLQEELGNAYKEIEYMKRVL
R
3D structure
PDB8ovw Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E231 R234 E11 R14
BS02 dna A H227 K228 R235 N239 S255 K256 H7 K8 R15 N19 S35 K36
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0019237 centromeric DNA binding
GO:0046983 protein dimerization activity
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007059 chromosome segregation
GO:0042762 regulation of sulfur metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061431 cellular response to methionine
GO:1900059 positive regulation of sulfate assimilation
GO:1900060 negative regulation of ceramide biosynthetic process
GO:1900090 positive regulation of inositol biosynthetic process
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005739 mitochondrion
GO:0089713 Cbf1-Met4-Met28 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ovw, PDBe:8ovw, PDBj:8ovw
PDBsum8ovw
PubMed37506202
UniProtP17106|CBF1_YEAST Centromere-binding protein 1 (Gene Name=CBF1)

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