Structure of PDB 8ovh Chain A

Receptor sequence
>8ovhA (length=400) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MPSHFDTVQLHAGQENSRAVPIYATTSYNPTSNVLEERIAALEGGAAALA
VSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFV
EGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVV
DNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKD
YPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFAS
FLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHEN
AKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANV
GDAKTLVIAPYFTTGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP
3D structure
PDB8ovh Enzymatic Synthesis of l-Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade.
ChainA
Resolution2.171 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.47: cysteine synthase.
2.5.1.49: O-acetylhomoserine aminocarboxypropyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G86 Q87 Q90 Y111 D183 T185 S206 T208 K209 G54 Q55 Q58 Y79 D151 T153 S174 T176 K177
Gene Ontology
Molecular Function
GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0030170 pyridoxal phosphate binding
GO:0051009 O-acetylhomoserine sulfhydrylase activity
Biological Process
GO:0000103 sulfate assimilation
GO:0006520 amino acid metabolic process
GO:0006535 cysteine biosynthetic process from serine
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:0071266 'de novo' L-methionine biosynthetic process
GO:0071269 L-homocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ovh, PDBe:8ovh, PDBj:8ovh
PDBsum8ovh
PubMed37235813
UniProtP06106|CYSD_YEAST Homocysteine/cysteine synthase (Gene Name=MET17)

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