Structure of PDB 8ouv Chain A

Receptor sequence
>8ouvA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDG
KKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGS
PLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVH
RDLAARNCMLDEKFTVKVADFGLARVMYDKEYYSVHNKTGAKLPVKWMAL
ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRL
LQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB8ouv Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
ChainA
Resolution1.783 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W3R A K1110 F1124 M1131 L1140 L1142 V1155 F1200 V1220 A1221 D1222 A1226 R1227 K58 F72 M79 L88 L90 V103 F148 V168 A169 D170 A174 R175
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8ouv, PDBe:8ouv, PDBj:8ouv
PDBsum8ouv
PubMed37343272
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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