Structure of PDB 8ouu Chain A

Receptor sequence
>8ouuA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
NPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCA
VKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLP
YMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAAR
NCMLDEKFTVKVADFGLARVMYDKEYYSVHAKLPVKWMALESLQTQKFTT
KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL
YEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB8ouu Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W49 A K1110 L1112 F1124 M1131 L1140 L1142 V1155 L1157 F1200 V1220 A1221 D1222 A1226 R1227 K52 L54 F66 M73 L82 L84 V97 L99 F142 V162 A163 D164 A168 R169
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ouu, PDBe:8ouu, PDBj:8ouu
PDBsum8ouu
PubMed37343272
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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