Structure of PDB 8out Chain A

Receptor sequence
>8outA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRK
LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWS
MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGGTVAWMAPEVI
RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP
SSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKS
QAEWREEVKLHFEKIKS
3D structure
PDB8out Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
ChainA
Resolution1.935 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W3C A V131 G132 S133 Q136 V139 A150 M190 F192 C193 A194 G196 Q197 L243 V14 G15 S16 Q19 V22 A33 M73 F75 C76 A77 G79 Q80 L126
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8out, PDBe:8out, PDBj:8out
PDBsum8out
PubMed37436942
UniProtQ12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (Gene Name=MAP3K12)

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