Structure of PDB 8our Chain A

Receptor sequence
>8ourA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
WEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRK
LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWS
MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGGTVAWMAPEVI
RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVP
SSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKS
QAEWREEVKLHFEK
3D structure
PDB8our Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W38 A G132 Q136 V139 A150 M190 F192 C193 G196 Q197 L243 G15 Q19 V22 A33 M73 F75 C76 G79 Q80 L126
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8our, PDBe:8our, PDBj:8our
PDBsum8our
PubMed37436942
UniProtQ12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 (Gene Name=MAP3K12)

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