Structure of PDB 8orw Chain A

Receptor sequence
>8orwA (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]
NVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQR
AGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAS
QNNCRLIAYQEPSLSQEVLRHLRQE
3D structure
PDB8orw Crystal structure of human STING in complex with the agonist MD1203
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VZ6 A S162 Y163 Y167 I235 R238 Y240 T263 P264 S9 Y10 Y14 I82 R85 Y87 T110 P111
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:8orw, PDBe:8orw, PDBj:8orw
PDBsum8orw
PubMed38325369
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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