Structure of PDB 8orq Chain A

Receptor sequence
>8orqA (length=901) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
MKKVIGSIEFGILSPQEIRKMSAVEVTVPDTYDDDGYPIEGGVMDKRMGV
IDPGLRCETCGGRAGECPGHFGHIELARPVIHVGFAKTIYRILESTCREC
GRIKLTDEEIEEYMKKIELARNRRSEFNEIIKEIHKKAKERMVCPHCGAP
QYPIKFEKPTIYWEIRKDEQGNEYRHRLMPTEVRDWLEKIPDKDLPLLGL
DPEKSRPEWMVLTVLPVPPVTARPSITLETGIRAEDDLTHKLVDIIRINN
RLKQNIEAGAPQLIIEDLWDLLQYHVTTYINNEAPGVPPAKHKSGRPLKT
LAQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPVEVAMEL
TVPEKVTEFNIERLRKMVLNGPDKYPGANYVIDPEGRRRRIMDSNKETLA
NQLDIGWTVERHLMDGDIVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLA
VCPPYNADFDGDEMNLHVPQTEEAQAEARILMEVQNHIISPRYGGPIIGG
IQDHISGGYLLTREGAYFTRDEVEQMLMFAGVDITELPEPDKYDENGNPL
WSGKTIFSLLLPEDLTVWYRNKLCDEPERCEALEKLIEEKLMPDPEEVRK
LAYDGFVYIQNGKLLSGAIDKKAYGREDGIILDLIVREYGVERARQFLDQ
VTKLTIWVITHKGFTTGIDDEDLPEEARDRIREIIREAEERVNKLIEAYK
RGELEPLPGKSLEDTLESLIMAVLAEARDNAGAVAEKYLGMDNHTVIMAK
TGARGKILNITQMAALLGQQSIRGKRLYRGFRGRVLSHFKPGDLGARAKG
FVVNSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDL
KVEYDGTVRSPEGIIVQFKYGEDGVDPMKSWRGKTVDVDRIIVRTLLKMR
G
3D structure
PDB8orq Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D458 D460 D462 D458 D460 D462
BS02 ZN A C57 C60 C67 H70 C57 C60 C67 H70
BS03 ZN A C97 C100 C144 C147 C97 C100 C144 C147
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8orq, PDBe:8orq, PDBj:8orq
PDBsum8orq
PubMed38709902
UniProtQ8U0M4

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