Structure of PDB 8oqt Chain A

Receptor sequence
>8oqtA (length=729) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SSHHHHHHSMPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKA
VDRLVAEKDSITGVVVASAKKTFFAGGDVKTMIQARPEDAGDVFNTVETI
KRQLRTLETLGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPE
VTLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAKAKEIGLVDELV
ATVEELVPAAKAWIKEELKANPDGAGVQPWDKKGYKMPGGTPSSPGLAAI
LPSFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDFDTASRIESRYFASLV
TGQVAKNMMQAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAGMMGAGIA
YVSAKAGYEVVLKDVSLEAAAKGKGYSEKLEAKALERGRTTQERSDALLA
RITPTADAADFKGVDFVIEAVFENQELKHKVFGEIEDIVEPNAILGSNTS
TLPITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFD
YTLAIGKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVEPASIEQAGSQ
AGYPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPHPAEAVVEKMI
ELGRSGRLKGAGFYEYADGKRSGLWPGLRETFKSGSSQPPLQDMIDRMLF
AEALETQKCLDEGVLTSTADANIGSIMGIGFPPWTGGSAQFIVGYSGPAG
TGKAAFVARARELAAAYGDRFLPPESLLS
3D structure
PDB8oqt Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis beta-oxidation trifunctional enzyme.
ChainA
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VXC A G67 G68 V70 M73 P140 E141 G76 G77 V79 M82 P149 E150
BS02 VXC A H-9 E32 D69 T87 H5 E41 D78 T96
BS03 VXC A D80 V84 T87 D89 V93 T96
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016491 oxidoreductase activity
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016829 lyase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009056 catabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oqt, PDBe:8oqt, PDBj:8oqt
PDBsum8oqt
PubMed39012716
UniProtO53872

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