Structure of PDB 8opt Chain A

Receptor sequence
>8optA (length=783) Species: 9606 (Homo sapiens) [Search protein sequence]
PVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNYPTAKYTCRLCDV
LIESIAFAHKHIKEKRHKKNIKEKQEEELLTTLPPPTPSQINAVGIAIDK
VVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSLRLYGSSCSRLGFKNS
DVNIDIQFPAIMSQPDVLLLVQECLKNSDSFIDVDADFHARVPVVVCREK
QSGLLCKVSAGNENACLTTKHLTALGKLEPKLVPLVIAFRYWAKLCSIDR
PEEGGLPPYVFALMAIFFLQQRKEPLLPVYLGSWIEGFSLSKLGNFNLQD
IEKDVVIWEHTDSPIKRGQVSLILDVKHQPSVPVGQLWVELLRFYALEFN
LADLVISIRVKELVSRELKDWPKKRIAIEDPYSVKRNVARTLNSQPVFEY
ILHCLRTTYKYFADFFYEFSKLIFTKGKSPTVVCSLCKREGHLKKDCPED
FKRILEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESF
IRQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLGLDCVRTIEELARV
LRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSA
YSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNP
PVIPVLQEIPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLL
RFYTEEFDFKEHVISIRRKSLLTTFKKQWTIVIEDPFDLNHNLGAGLSRK
MTNFIMKAFINGRRVFGIPVYPSKMEYFFDPDV
3D structure
PDB8opt Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
ChainA
Resolution3.65 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R223 H260 K264 E265 K266 R267 P613 K969 R970 E971 R22 H59 K63 E64 K65 R66 P396 K438 R439 E440
BS02 ZN A C965 C968 H973 C434 C437 H442
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0035198 miRNA binding
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0001556 oocyte maturation
GO:0010586 miRNA metabolic process
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
GO:0071044 histone mRNA catabolic process
GO:0071076 RNA 3' uridylation
GO:0141008 retrotransposon silencing by mRNA destabilization
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8opt, PDBe:8opt, PDBj:8opt
PDBsum8opt
PubMed39054354
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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