Structure of PDB 8opp Chain A

Receptor sequence
>8oppA (length=670) Species: 9606 (Homo sapiens) [Search protein sequence]
PTPSQINAVGIAIDKVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDCSL
RLYGSSCSRLGFKNSDVNIDIQFPAIMSQPDVLLLVQECLKNSDSFIDVD
ADFHARVPVVVCREKQSGLLCKVSAGNENACLTTKHLTALGKLEPKLVPL
VIAFRYWAKLCSIDRPEEGGLPPYVFALMAIFFLQQRKEPLLPVYLGSWI
EGFSLSKLGNFNLQDIEKDVVIWEHTPIKRGQVSLILDVKHQPSVPVGQL
WVELLRFYALEFNLADLVISIRVKELVSRELKDWPKKRIAIEDPYSVKRN
VARTLNSQPVFEYILHCLRTTYKYFATKGKSPTVVCSLCKREGHLKKDCP
EDFKLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQ
DFPGTKLSLFGSSKNGFGFKQSDLDVCMTIVRTIEELARVLRKHSGLRNI
LPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKY
LCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEIG
WNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISI
RRKSLLTTFKKQWTSIVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRV
FGIPVKPSKMEYFFDPDVLT
3D structure
PDB8opp Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
ChainA
Resolution3.76 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R592 I1099 T1101 K1103 I1106 D1119 N1124 S1164 R288 I453 T455 K457 I460 D473 N478 S518
BS02 P5E A F1045 S1047 D1058 L1059 D1060 A1127 S1170 Y1171 F410 S412 D423 L424 D425 A481 S524 Y525
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0035198 miRNA binding
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0001556 oocyte maturation
GO:0010586 miRNA metabolic process
GO:0031054 pre-miRNA processing
GO:0031123 RNA 3'-end processing
GO:0071044 histone mRNA catabolic process
GO:0071076 RNA 3' uridylation
GO:0141008 retrotransposon silencing by mRNA destabilization
GO:1990074 polyuridylation-dependent mRNA catabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8opp, PDBe:8opp, PDBj:8opp
PDBsum8opp
PubMed39054354
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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