Structure of PDB 8omr Chain A

Receptor sequence
>8omrA (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]
PRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLD
ALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVS
LVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVS
STVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQNLFAIIQGGLDADLRATC
LEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGY
ATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPI
DPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAVRTS
IVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG
3D structure
PDB8omr Novel structural and functional insights into human tRNA guanine transglycosylase
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.64: tRNA-guanosine(34) queuine transglycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A T50 K55 H76 F109 L114 P130 Y131 G260 V261 Y263 D279 C280 V281 R285 R288 F289 K303 T37 K42 H63 F96 L101 P117 Y118 G247 V248 Y250 D266 C267 V268 R272 R275 F276 K290
BS02 ZN A C317 C319 C322 H348 C304 C306 C309 H335
BS03 9DG A D105 D159 D92 D146
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032991 protein-containing complex
GO:0120507 tRNA-guanine transglycosylase complex
GO:1990234 transferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8omr, PDBe:8omr, PDBj:8omr
PDBsum8omr
PubMed38181786
UniProtQ9BXR0|TGT_HUMAN Queuine tRNA-ribosyltransferase catalytic subunit 1 (Gene Name=QTRT1)

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