Structure of PDB 8omk Chain A

Receptor sequence
>8omkA (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
PRGSQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVL
SLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCI
INNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKML
QRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLG
FQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRV
VDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
3D structure
PDB8omk Discovery of BI-9787, a Potent Zwitterionic KHK-Inhibitor with Oral Bioavailability
ChainA
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.3: ketohexokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F1X A D15 G41 N42 N45 R108 L112 G255 D258 D15 G41 N42 N45 R108 L112 G255 D258
BS02 ADP A A224 A226 G229 P246 A256 G257 C282 A285 C289 A224 A226 G229 P246 A256 G257 C282 A285 C289
Gene Ontology
Molecular Function
GO:0004454 ketohexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0070061 fructose binding
Biological Process
GO:0006000 fructose metabolic process
GO:0006796 phosphate-containing compound metabolic process
GO:0009744 response to sucrose
GO:0009749 response to glucose
GO:0009750 response to fructose
GO:0010043 response to zinc ion
GO:0016310 phosphorylation
GO:0032868 response to insulin
GO:0046835 carbohydrate phosphorylation
GO:0070873 regulation of glycogen metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8omk, PDBe:8omk, PDBj:8omk
PDBsum8omk
PubMed39179180
UniProtP50053|KHK_HUMAN Ketohexokinase (Gene Name=KHK)

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