Structure of PDB 8omi Chain A

Receptor sequence
>8omiA (length=240) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
PDGQYLLKPCLSHRERDFYLHIKDDKEWTGTGIIPKFYGVELHEFGFGEL
EFIRVENLMYKYKRPFVLDLKIGTQTWDPETASSKMKKRLVVDSTSTTTS
LGVRFSGMERNIGEEKPILYSRYLCTHEVNTRDSLKEYIKLFFNDGKKYR
KELVPYFISQLDKMIEVMKKREYKMFSSSVLFVYDSTTTLEDKKYNCKMI
DFAHNWILSEEECTVEDGFLFGLNNLKSILEDIENEFKSL
3D structure
PDB8omi An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A K38 E86 N87 L88 I230 D231 K8 E56 N57 L58 I200 D201
Gene Ontology
Molecular Function
GO:0000828 inositol hexakisphosphate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0046854 phosphatidylinositol phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8omi, PDBe:8omi, PDBj:8omi
PDBsum8omi
PubMed37843983
UniProtC4M387

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