Structure of PDB 8oku Chain A

Receptor sequence
>8okuA (length=338) Species: 9606 (Homo sapiens) [Search protein sequence]
MHHHHHHLVPRGSPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKI
IDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYAS
GGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLL
DANLNIKIADFGFSNLFTPGQLLKDWCGSPPYAAPELFEGKEYDGPKVDI
WSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRH
MLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQPLNEDVLLAME
DMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTL
3D structure
PDB8oku Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VRU A I72 K74 V80 A93 K95 T142 Y144 A145 S146 G148 L195 D206 I26 K28 V34 A47 K49 T96 Y98 A99 S100 G102 L149 D160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8oku, PDBe:8oku, PDBj:8oku
PDBsum8oku
PubMed38147525
UniProtQ9Y2K2|SIK3_HUMAN Serine/threonine-protein kinase SIK3 (Gene Name=SIK3)

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