Structure of PDB 8ojc Chain A

Receptor sequence
>8ojcA (length=395) Species: 10306 (Human alphaherpesvirus 1 strain KOS) [Search protein sequence]
TGPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCG
GDERDVLRVGSGGFWPRRSRLWGGVDVFHVYDILENVEGTVITLLGLTPE
GHRVAVHVYGTRTFGWYRLKAFGTSSDVEFNCTADNLAIEGGMSDLPAYK
LMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFS
LGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGPEFVT
GYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVFRVWDRSKIKVNGMV
NIDMYGIITDKIKLSSYKLNAVAEAVLKDKKKDLSYRDIPAYYAAGPAQR
GVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINITRTIYDG
3D structure
PDB8ojc Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM
ChainA
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E370 C371 F381 N466 F470 Y526 Y538 K539 L540 Y557 E157 C158 F168 N253 F257 Y305 Y317 K318 L319 Y336
BS02 CA A D368 Y465 D471 D155 Y252 D258
BS03 CA A D368 E370 D581 D155 E157 D360
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0042025 host cell nucleus
GO:0042575 DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ojc, PDBe:8ojc, PDBj:8ojc
PDBsum8ojc
PubMed38806233
UniProtP04293|DPOL_HHV11 DNA polymerase catalytic subunit (Gene Name=UL30)

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