Structure of PDB 8ohd Chain A

Receptor sequence
>8ohdA (length=692) Species: 9606 (Homo sapiens) [Search protein sequence]
ERNCIEIVNKLIAQKQLEVVHTLDGKEYITPAQISKEMRDELHVRGGRVN
IVDLQQVINVDLIHIENRIGDIIKSEKHVQLVLGQLIDENYLDRLAEEVN
DKLQESGQVTISELCKTYDLPGNFLTQALTQRLGRIISGHIDLDNRGVIF
TEAFVARHKARIRGLFSAITRPTAVNSLISKYGFQEQLLYSVLEELVNSG
RLRGTVVGGRQDKAVFVPDIYSRTQSTWVDSFFRQNGYLEFDALSRLGIP
DAVSYIKKRYKTTQLLFLKAACVGQGLVDQVEASVEEAISSGTWVDIAPL
LPTSLSVEDAAILLQQVMRAFSKQASTVVFSDTVVVSEKFINDCTELFRE
LMHQKAEKEMKDKKDERRRKATEGSGSMRGGGGGNAREYKIKKVQDEIED
FLRKHIQDAPEEFISELAEYLIKPLNKTYLEVVRSVFMSSTTSASGTGRK
RTIKDLQEEVSNLYNNIRLFEKGMKFFADDTQAALTKHLLKSVCTDITNL
IFNFLASDLMMAVDDPAAITSEIRKKILSKLSEETKVALTKLHNSLNEKS
IEDFISCLDSAAEACDIMVKRGDKKRERQILFQHRQALAEQLKVTEDPAL
ILHLTSVLLFQFSTHSMLHAPGRCVPQIIAFLNSKIPEDQHALLVKYQGL
VVKQLVSQSKKTGLDKEQEDVASTTRKELQELSSSIKDLVLK
3D structure
PDB8ohd UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0019901 protein kinase binding
GO:0061666 UFM1 ligase activity
GO:0071568 UFM1 transferase activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0001649 osteoblast differentiation
GO:0002841 negative regulation of T cell mediated immune response to tumor cell
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0008284 positive regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0030218 erythrocyte differentiation
GO:0031397 negative regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032790 ribosome disassembly
GO:0032880 regulation of protein localization
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034976 response to endoplasmic reticulum stress
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of canonical NF-kappaB signal transduction
GO:0050727 regulation of inflammatory response
GO:0050821 protein stabilization
GO:0050868 negative regulation of T cell activation
GO:0060218 hematopoietic stem cell differentiation
GO:0060252 positive regulation of glial cell proliferation
GO:0061709 reticulophagy
GO:0071569 protein ufmylation
GO:0072344 rescue of stalled ribosome
GO:0140501 positive regulation of reticulophagy
GO:1902065 response to L-glutamate
GO:1903052 positive regulation of proteolysis involved in protein catabolic process
GO:1903895 negative regulation of IRE1-mediated unfolded protein response
GO:1990592 protein K69-linked ufmylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0035861 site of double-strand break
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ohd, PDBe:8ohd, PDBj:8ohd
PDBsum8ohd
PubMed38383785
UniProtO94874|UFL1_HUMAN E3 UFM1-protein ligase 1 (Gene Name=UFL1)

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