Structure of PDB 8ogh Chain A

Receptor sequence
>8oghA (length=549) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GMLQQIRGPADLQHLSQAQLRELAAEIREFLIHKVAATGGHLGPNLGVVE
LTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRSQDFATLRKKGGLSGYP
SRAESEHDWVESSHASAALSYADGLAKAFELTGHRNRHVVAVVGDGALTG
GMCWEALNNIAASRRPVIIVVNDNGRSYGGGPQLLFTDLGLKYVGPVDGH
DERAVEVALRSARRFGAPVIVHVVTRKGMGYPPAEGPGWTATFSDALIGY
AQKRRDIVAITAAMPGPTGLTAFGQRFPDRLFDVGIAEQHAMTSAAGLAM
GGLHPVVAIYSTFLNRAFDQIMMDVALHKLPVTMVLDRAGITGSDGASHN
GMWDLSMLGIVPGIRVAAPRDATRLREELGEALDVDDGPTALRFPKGDVG
EDISALERRGGVDVLAAPADGLNHDVLLVAIGAFAPMALAVAKRLHNQGI
GVTVIDPRWVLPVSDGVRELAVQHKLLVTLEDNGVNGGAGSAVSAALRRA
EIDVPCRDVGLPQEFYEHASRSEVLADLGLTDQDVARRITGWVAALGTG
3D structure
PDB8ogh Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VMI A H40 P43 T69 H71 A114 G143 D144 G145 A146 N173 I363 E365 F390 D422 H41 P44 T70 H72 A115 G144 D145 G146 A147 N174 I286 E288 F313 D345
BS02 MG A D144 N173 D145 N174
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ogh, PDBe:8ogh, PDBj:8ogh
PDBsum8ogh
PubMed
UniProtP9WNS3|DXS_MYCTU 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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