Structure of PDB 8ogc Chain A

Receptor sequence
>8ogcA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
FRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEA
SYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTED
HYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCAT
FNPTDDLVLNDGVLWDVRSALAIHKFDKFNMNISGVFHPNGLEVIINTEI
WDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQAMKSPFGSSFRTFNA
TDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEV
3D structure
PDB8ogc Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
ChainA
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S1084 F1123 S5 F44
BS02 VMZ A T1097 T1139 H1140 H1180 R1225 C1227 R1298 L1313 M1326 P1329 F1330 F1355 D1356 T18 T60 H61 H101 R146 C148 R219 L234 M237 P240 F241 F266 D267
BS03 VMZ A R1104 L1117 E1128 A1129 Y1131 M1166 R25 L38 E49 A50 Y52 M87
Gene Ontology
Biological Process
GO:0016567 protein ubiquitination

View graph for
Biological Process
External links
PDB RCSB:8ogc, PDBe:8ogc, PDBj:8ogc
PDBsum8ogc
PubMed37465299
UniProtQ9Y4B6|DCAF1_HUMAN DDB1- and CUL4-associated factor 1 (Gene Name=DCAF1)

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