Structure of PDB 8og5 Chain A

Receptor sequence
>8og5A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
FRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEA
SYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTED
HYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCAT
FNPTDDLVLNDGVLWDVRSALAIHKFDKFNMNISGVFHPNGLEVIINTEI
WDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDSSFRTFNATDYK
PIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVG
3D structure
PDB8og5 Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LQH A T1139 R1298 L1313 A1315 D1316 D1356 T60 R219 L234 A236 D237 D263
BS02 LQH A M1166 V1169 F1170 M87 V90 F91
BS03 LQH A L1236 I1252 L1282 R1283 F1285 L157 I173 L203 R204 F206
Gene Ontology
Biological Process
GO:0016567 protein ubiquitination

View graph for
Biological Process
External links
PDB RCSB:8og5, PDBe:8og5, PDBj:8og5
PDBsum8og5
PubMed37465299
UniProtQ9Y4B6|DCAF1_HUMAN DDB1- and CUL4-associated factor 1 (Gene Name=DCAF1)

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