Structure of PDB 8og2 Chain A

Receptor sequence

>8og2A (length=531) Species: 10090 (Mus musculus)

MGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD
YFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV
YKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTDTLDPEPFVDCKEC
GRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGN
HLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMS
ESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDS
IHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHC
HPPDQKIPKPKRLQEWFKKMLDKAFAERIINDYKDIFKQANEDRLTSAKE
LPYFEGDFWPNVLEESIKEKLYATMEKHKEVFFVIHLHPPIVDPDPLLSC
DLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCN
ECKHHVETRWHCTVCEDYDLCINHTHKMVKW

3D structure

• PDB: 8og2 Crystal structure of CREBBP histone acetyltransferase domain in complex with Coenzyme A
• Chain: A
• Resolution: 2.47 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C1199 C1200 H1291 C1294	C125 C126 H155 C158
BS02	ZN	A	C1283 C1286 C1308 C1311	C147 C150 C172 C175
BS03	ZN	A	C1710 C1729	C502 C521
BS04	ZN	A	Y1726 H1738 H1740	Y518 H524 H526
BS05	COA	A	L1434 S1436 R1446 T1447 Y1450 P1476 Y1482 K1492 I1493 P1494 K1495 R1498 L1499 W1502 F1503	L298 S300 R310 T311 Y314 P340 Y346 K356 I357 P358 K359 R362 L363 W366 F367

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:8og2, PDBe:8og2, PDBj:8og2
• PDBsum: 8og2
• UniProt: P45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)