Structure of PDB 8ofi Chain A

Receptor sequence
>8ofiA (length=452) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
MLQPGVNKFSLRMFGSQKAVEREQERVIHPYSDFRFYWDLTMLLLMVGNL
IIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRIKMKYLKSWFVV
DFVSSIPVDYIFLIVETARALRIVRFTKILSLLRLLRLSRLIRYIHQWEE
IFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSL
NNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGA
TCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHD
YYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNF
VTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLA
DGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF
ET
3D structure
PDB8ofi Structural determinants of ivabradine block of the open pore of HCN4.
ChainA
Resolution3.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VNZ A A504 Y507 A250 Y253
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