Structure of PDB 8of2 Chain A

Receptor sequence
>8of2A (length=249) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKE
RSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTP
LVQKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCM
AFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKD
KWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA
3D structure
PDB8of2 The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3AY A S95 F97 Y174 S94 F96 Y155
BS02 NDP A R14 I15 Y34 H35 N36 S37 L63 N93 S95 T126 L159 K178 P204 G205 S207 L208 R13 I14 Y33 H34 N35 S36 L62 N92 S94 T116 L140 K159 P185 G186 S188 L189
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:8of2, PDBe:8of2, PDBj:8of2
PDBsum8of2
PubMed38043491
UniProtQ581W1

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