Structure of PDB 8oes Chain A

Receptor sequence

>8oesA (length=1168) Species: 9606 (Homo sapiens)

AHNGRVCSTWGDFHYKTFDGDVFRFPGLCNYVFSEHCRAAYEDFNVQLRR
GLVGSRPVVTRVVIKAQGLVLEASNGSVLINGQREELPYSRTGLLVEQSG
DYIKVSIRLVLTFLWNGEDSALLELDPKYANQTCGLCGDFNGLPAFNEFY
AHNARLTPLQFGNLQKLDGPTEQCPDPLPLPAGNCTDEEGICHRTLLGPA
FAECHALVDSTAYLAACAQDLCRCPTCPCATFVEYSRQCAHAGGQPRNWR
CPELCPRTCPLNMQHQECGSPCTDTCSNPQRAQLCEDHCVDGCFCPPGTV
LDDITHSGCLPLGQCPCTHGGRTYSPGTSFNTTCSSCTCSGGLWQCQDLP
CPGTCSVQGGAHISTYDEKLYDLHGDCSYVLSKKCADSSFTVLAELRKCG
LTDNENCLKAVTLSLDGGDTAIRVQADGGVFLNSIYTQLPLSAANITLFT
PSSFFIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLCGNFNQNQA
DDFTALSGVVEATGAAFANTWKAQAACANARNSFEDPCSLSVENENYARH
WCSRLTDPNSAFSRCHSIINPKPFHSNCMFDTCNCERSEDCLCAALSSYV
HACAAKGVQLSDWRDGVCTKYMQNCPKSQRYAYVVDACQPTCRGLSEADV
TCSVSFVPVDGCTCPAGTFLNDAGACVPAQECPCYAHGTVLAPGEVVHDE
GAVCSCTGGKLSCLGGCAAPMVYLDCSNSSAGTPGAECLRSCHTLDVGCF
STHCVSGCVCPPGLVSDGSGGCIAEEDCPCVHNEATYKPGETIRVDCNTC
TCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSFEGSCEYILAQDYCG
DNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVESYELILQEGTFKAVARG
PGGDPPYKIRYMGIFLVIETHGMAVSWDRKTSVFIRLHQDYKGRVCGLCG
NFDDNAINDFATRSRSVVGDALEFGNSWKLSPSCPDALAPKDPCTANPFR
KSWAQKQCSILHGPTFAACRSQVDSTKYYEACVNDACACDSGGDCECFCT
AVAAYAQACHDAGLCVSWRTPDTCPLFCDFYNPHGGCEWHYQPCGAPCLK
TCRNPSGHCLVDLPGLEGCYPKCPPSQPFFNEDQMKCVAQCGCYDKDGNY
YDVGARVPCNCTPSGIQC

3D structure

• PDB: 8oes Pulmonary Fibrosis Linked to Impaired Mucin 5B Supramolecular Assembly
• Chain: A
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D907 N1028 D1030 N1032 N1035 D1036	D830 N951 D953 N955 N958 D959
BS02	CA	A	D209 N211 L213 N217 E218	D139 N141 L143 N147 E148
BS03	CA	A	D437 N564 N566 N568 D571	D367 N494 N496 N498 D501

External links

• PDB: RCSB:8oes, PDBe:8oes, PDBj:8oes
• PDBsum: 8oes
• UniProt: Q9HC84|MUC5B_HUMAN Mucin-5B (Gene Name=MUC5B)