Structure of PDB 8kho Chain A

Receptor sequence
>8khoA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
SHSIVLPAAVSSAHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLH
QACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFP
KSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGN
VDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPH
FVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLE
DAWTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA
3D structure
PDB8kho Structural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MET A F147 C152 D178 D189 H259 E284 E315 F99 C104 D130 D141 H211 E236 E267
BS02 CO A D189 H252 T282 E284 E315 D141 H204 T234 E236 E267
BS03 CO A D178 D189 E315 D130 D141 E267
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8kho, PDBe:8kho, PDBj:8kho
PDBsum8kho
PubMed38102161
UniProtQ6UB28|MAP12_HUMAN Methionine aminopeptidase 1D, mitochondrial (Gene Name=METAP1D)

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