Structure of PDB 8kh4 Chain A

Receptor sequence
>8kh4A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
IITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLL
SVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDRY
YAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKW
MCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKACKALITI
LVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPL
IYGLWNKTVRKELLGM
3D structure
PDB8kh4 Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A V274 A278 L326 W327 V202 A206 L254 W255
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8kh4, PDBe:8kh4, PDBj:8kh4
PDBsum8kh4
PubMed37737235
UniProtQ8N6U8|GP161_HUMAN G-protein coupled receptor 161 (Gene Name=GPR161)

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