Structure of PDB 8k7b Chain A

Receptor sequence
>8k7bA (length=590) Species: 9606 (Homo sapiens) [Search protein sequence]
TWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYR
NIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRV
QQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYL
VFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTK
FRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLE
WKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYI
IQLYMPLNAFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQK
GRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLF
RFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYG
RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAI
ARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLST
VVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQG
3D structure
PDB8k7b W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state.
ChainA
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.5: ABC-type heme transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AOV A Y599 G626 G628 K629 S630 T631 H783 Y362 G389 G391 K392 S393 T394 H546
BS02 MG A S630 Q671 S393 Q434
BS03 AOV A K726 L727 S728 G729 K489 L490 S491 G492
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k7b, PDBe:8k7b, PDBj:8k7b
PDBsum8k7b
PubMed37735522
UniProtQ9NP58|ABCB6_HUMAN ATP-binding cassette sub-family B member 6 (Gene Name=ABCB6)

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