Structure of PDB 8k78 Chain A

Receptor sequence
>8k78A (length=298) Species: 9606 (Homo sapiens) [Search protein sequence]
QNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTL
LDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICL
RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS
KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPV
KWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLL
QGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI
3D structure
PDB8k78 Structural insight into the macrocyclic inhibitor TPX-0022 of c-Met and c-Src.
ChainA
Resolution2.67 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IYC A I1084 A1108 L1157 Y1159 M1160 M1211 A1221 D1222 A1226 Y1230 I37 A61 L110 Y112 M113 M164 A174 D175 A179 Y183
External links
PDB RCSB:8k78, PDBe:8k78, PDBj:8k78
PDBsum8k78
PubMed38074469
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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