Structure of PDB 8k5b Chain A

Receptor sequence
>8k5bA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
HFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKS
WKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLA
MNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGL
TVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCS
ARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLL
HTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSP
3D structure
PDB8k5b Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2
ChainA
Resolution3.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NIO A R111 S178 S179 Y284 R103 S170 S171 Y276
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0070553 nicotinic acid receptor activity
Biological Process
GO:0001781 neutrophil apoptotic process
GO:0006915 apoptotic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
GO:0033031 positive regulation of neutrophil apoptotic process
GO:0050995 negative regulation of lipid catabolic process
GO:0070165 positive regulation of adiponectin secretion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:8k5b, PDBe:8k5b, PDBj:8k5b
PDBsum8k5b
PubMed37932263
UniProtQ8TDS4|HCAR2_HUMAN Hydroxycarboxylic acid receptor 2 (Gene Name=HCAR2)

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