Structure of PDB 8k1l Chain A

Receptor sequence
>8k1lA (length=979) Species: 85549 (Artemia salina) [Search protein sequence]
LDQHKIPLEELCRRLGTNTETGLTSSQAKSHLEKYGPNALTPPRTTPEWI
KFCKQLFGGFQMLLWIGSILCFIAYTMEKYKNPDVLGDNLYLGLALLFVV
IMTGCFAYYQDHNASKIMDSFKNLMPQFAFVIRDGKKIQLKAEEVTVGDL
VEVKFGDRIPADIRITSCQSMKVDNSSLTGESEPQSRSTECTNDNPLETK
NLAFFFTNTLEGTGRGIVINVGDDSVMGRIACLASSLDSGKTPIAREIEH
FIHIITAMAVSLAAVFAVISFLYGYTWLEAAIFMIGIIVAKVPEGLLATV
TVCLTLTAKRMAKKNCLVRNLEAVETLGSTSTICSDKTGTLTQNRMTVAH
MWFDQKIVTADTTENQSGNQLYRGSKGFPELIRVASLCSRAEFKTEHAHL
PVLKRDVNGDASEAAILKFAEMSTGSVMNIRSKQKKVSEIPFNSANKYQV
SVHEREDKSGYFLVMKGAPERILERCSTILIDGTEIPLDNHMKECFNNAY
MELGGMGERVLGFCDFELPSDQYPRGYVFDADEPNFPISGLRFVGLMSMI
DPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIARQVGIISEGHETVD
DIAARLNIPVSEVNPRSAQAAVIHGNDLKDMNSDQLDDILRHYREIVFAR
TSPQQKLIIVEGVQRQGEFVAVTGDGVNDSPALKKADIGVAMGIAGSDVS
KQAADMILLDDNFASIVTGVEEGRLIFDNIKKSIAYTLTSKIPELSPFLM
YILFDLPLAIGTVTILCIDLGTDVVPAISMAYEGPEADPRKPRDPVKEKL
VNERLISMAYGQIGVMQAFGGFFTYFVIMGECGFLPNRLFGLRKWWESKA
YNDLTDSYGQEWTWDARKQLEYTCHTAFFISIVIVQWTDLIICKTRRLSL
FQQGMKNGTLNFALVFETCVAAFLSYTPGMDKGLRMYPLKIWWWFPPMPF
SLLILVYDECRKFLMRRNPGGFLERETYY
3D structure
PDB8k1l A Na pump with reduced stoichiometry is upregulated by brine shrimp in extreme salinities.
ChainA
Resolution3.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF A T196 G197 D353 T355 T592 K673 N695 T179 G180 D336 T338 T575 K656 N678
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k1l, PDBe:8k1l, PDBj:8k1l
PDBsum8k1l
PubMed38079564
UniProtP17326|AT1A_ARTSF Sodium/potassium-transporting ATPase subunit alpha-A

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