Structure of PDB 8k14 Chain A

Receptor sequence
>8k14A (length=131) Species: 9606 (Homo sapiens) [Search protein sequence]
LVPRGSNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPV
DAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCY
IYNKPGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB8k14 Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation.
ChainA
Resolution1.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VFI A W81 F83 L92 Y139 D145 I146 M149 W44 F46 L55 Y102 D108 I109 M112
External links
PDB RCSB:8k14, PDBe:8k14, PDBj:8k14
PDBsum8k14
PubMed37992518
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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