Structure of PDB 8jyh Chain A

Receptor sequence
>8jyhA (length=144) Species: 587638 (HIV-1 06TG.HT008) [Search protein sequence]
MYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQ
KTELQAIYLALQDSGLEVNIVTDSQYALGIITQWIHNWKKRGWKTPVKNV
DLVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKV
3D structure
PDB8jyh Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid C
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D23 E58 D78 D18 E53 D73
BS02 MN A D23 D78 D139 D18 D73 D134
BS03 V96 A D23 E58 D78 S79 Q80 Y81 A128 H129 D139 D18 E53 D73 S74 Q75 Y76 A123 H124 D134
BS04 ZN A H129 E136 H124 E131
BS05 ZN A E72 E119 E67 E114
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:8jyh, PDBe:8jyh, PDBj:8jyh
PDBsum8jyh
PubMed37874155
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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