Structure of PDB 8jxj Chain A

Receptor sequence

>8jxjA (length=570) Species: 10116 (Rattus norvegicus)

ECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCESGLFLCPA
EGTCIPSSWVCDEDKDCSDGADEQQNCAKPTHKPCTDTEYKCSNGNCISQ
HYVCDNVNDCGDLSDETGCNLGDNRTCAENICEQNCTQLSSGGFICSCRP
GFKPSTLDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHY
GERCAADGSPPLLLLPENVRIRKYNTSSEKFSEYLEEEEHIQTIDYDWDP
EHIGLSVVYYTVLAQGSQFGAIKRAYIPNFESGSNNPIREVDLGLKYLMQ
PDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVN
PKLGLMFWTDQGKQPKIESAWMNGEHRSVLVSENLGWPNGLSIDYLNDDR
VYWSDSKEDVIEAIKYDGTDRRLIINEAMKPFSLDIFEDKLYWVAKEKGE
VWRQNKFGKENKEKVLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCL
LRPGGYSCACPQGSDFVTGSTVQCDAASELPVTMPPPCRCMHGGNCYFDE
NELPKCKCSSGYSGEYCEVG

3D structure

• PDB: 8jxj Cryo-EM structures elucidate the multiligand receptor nature of megalin.
• Chain: A
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	A	Y4407 G4415	Y562 G570
BS02	CA	A	W45 D48 T50 D52 D58 E59	W19 D22 T24 D26 D32 E33
BS03	CA	A	W85 V86 D88 D90 D92 E99	W59 V60 D62 D64 D66 E73
BS04	CA	A	Y3947 D3950 V3952 D3954 D3960 E3961	Y102 D105 V107 D109 D115 E116
BS05	CA	A	D4009 I4010 E4012 N4025 S4026 G4028 S4029	D164 I165 E167 N180 S181 G183 S184

External links

• PDB: RCSB:8jxj, PDBe:8jxj, PDBj:8jxj
• PDBsum: 8jxj
• PubMed: 38771880
• UniProt: P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)