Structure of PDB 8jxg Chain A

Receptor sequence
>8jxgA (length=1114) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPASHT
CRSNEFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSVNTCRASQFQ
CDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSSTQFTCVNSRPPN
RRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSCANGRCVRQSFRC
DRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFVCDEDNDCGDGSD
EQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSDEKGCGIN
ECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSCVDIDECKESPQL
CSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPYLIFSNRYYIRNL
TTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQIIERMFLNKTNRE
TIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRHRKMIAQHCV
DANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIGMDGTNKSVIIST
KIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGSLPHPFA
LTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVYHPYRQ
PIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTVQLRDRTLCMPMC
SSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRLGQFQCRD
GNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQCANKRCIPQSWQ
CDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGD
YSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQ
GCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENCVPRECSES
EFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVP
KALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICD
GENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNGVDDCGDG
SDEKEEHCRKPTHK
3D structure
PDB8jxg Cryo-EM structures elucidate the multiligand receptor nature of megalin.
ChainA
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R3326 W3342 N3370 H3411 W3427 R3738 R512 W528 N556 H597 W613 R924
BS02 CA A W1249 D1252 H1254 D1256 D1262 E1263 W26 D29 H31 D33 D39 E40
BS03 CA A W2883 F2884 C2885 D2886 E2888 D2890 D2896 E2897 W69 F70 C71 D72 E74 D76 D82 E83
BS04 CA A W2925 D2928 G2929 D2930 D2932 D2938 E2939 W111 D114 G115 D116 D118 D124 E125
BS05 CA A W2972 D2975 D2977 A2978 D2979 D2985 E2986 W158 D161 D163 A164 D165 D171 E172
BS06 CA A F3012 D3015 R3017 D3019 D3025 E3026 F198 D201 R203 D205 D211 E212
BS07 CA A F3051 D3054 D3056 D3058 D3064 E3065 F237 D240 D242 D244 D250 E251
BS08 CA A R3094 N3097 V3099 D3101 D3107 E3108 R280 N283 V285 D287 D293 E294
BS09 CA A D3154 I3155 E3157 N3171 V3172 G3174 S3175 D340 I341 E343 N357 V358 G360 S361
BS10 CA A A3291 D3294 E3323 A477 D480 E509
BS11 CA A V3344 E3367 V530 E553
BS12 CA A A3386 H3387 P3410 A572 H573 P596
BS13 CA A W3532 D3535 Q3537 D3539 D3545 E3546 W718 D721 Q723 D725 D731 E732
BS14 CA A A3572 N3575 R3577 Q3578 D3579 D3585 E3586 A758 N761 R763 Q764 D765 D771 E772
BS15 CA A W3613 D3616 V3618 D3620 D3626 E3627 W799 D802 V804 D806 D812 E813
BS16 CA A W3654 D3657 D3659 D3661 D3667 E3668 W840 D843 D845 D847 D853 E854
BS17 CA A A3699 N3702 F3704 D3706 D3712 E3713 A885 N888 F890 D892 D898 E899
BS18 CA A W3739 D3742 T3744 D3746 D3752 E3753 W925 D928 T930 D932 D938 E939
BS19 CA A W3778 D3781 E3783 D3785 D3791 E3792 W964 D967 E969 D971 D977 E978
BS20 CA A L3817 D3820 R3822 D3824 D3830 E3831 L1003 D1006 R1008 D1010 D1016 E1017
BS21 CA A W3861 C3863 D3864 E3866 D3868 D3874 E3875 W1047 C1049 D1050 E1052 D1054 D1060 E1061
BS22 CA A Q3903 N3906 V3908 D3910 D3916 E3917 Q1089 N1092 V1094 D1096 D1102 E1103
External links
PDB RCSB:8jxg, PDBe:8jxg, PDBj:8jxg
PDBsum8jxg
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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