Structure of PDB 8jxd Chain A

Receptor sequence
>8jxdA (length=493) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RKPTHKPCTDTEYKCSNGNCISQHYVCDNVNDCGDLSDETGCNLGDNRTC
AENICEQNCTQLSSGGFICSCRPGFKPSTLDKNSCQDINECEEFGICPQS
CRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPLLLLPENVRIRKYNTS
SEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVYYTVLAQGSQFGAIKRAYI
PNFESGSNNPIREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVAT
LDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGEHR
SVLVSENLGWPNGLSIDYLNDDRVYWSDSKEDVIEAIKYDGTDRRLIINE
AMKPFSLDIFEDKLYWVAKEKGEVWRQNKFGKENKEKVLVVNPWLTQVRI
FHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQGSDFVTGSTVQCDAA
SELPVTMPPPCRCMHGGNCYFDENELPKCKCSSGYSGEYCEVG
3D structure
PDB8jxd Cryo-EM structures elucidate the multiligand receptor nature of megalin.
ChainA
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A Y3947 D3950 V3952 D3960 E3961 Y25 D28 V30 D38 E39
BS02 CA A D4009 I4010 E4012 N4025 S4026 G4028 S4029 D87 I88 E90 N103 S104 G106 S107
External links
PDB RCSB:8jxd, PDBe:8jxd, PDBj:8jxd
PDBsum8jxd
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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