Structure of PDB 8jxc Chain A

Receptor sequence
>8jxcA (length=1337) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KEFECGSGECILRAYVCDHDNDCEDNSDERNCNYDTCGGHQFTCSNGQCI
NQNWVCDGDDDCQDSGDEDGCESNQSHHRCYPREWACPGSGRCISIDKVC
DGVPDCPEGDDENNVTSGRTCGMGVCSVLNCEYQCHQTPFGGECFCPPGH
IINSNDSRTCIDFDDCQIWGICDQKCENRQGRHQCLCEEGYILERGQHCK
SSDSFSAASVIFSNGRDLLVGDLHGRNFRILAESKNRGMVMGVDFHYQKH
RVFWTDPMQEKVFSTDINGLNTQEILNVSVDTPENLAVDWINNKLYLVET
KVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQP
KVERAFMDGSNRKDLVTTKVGWPAGITLDLVSKRVYWVDSRYDYIETVTY
DGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKASKFTETNPQ
VYHQSSLRPHGVTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNGGLG
YRCKCEFGFELDDDEHRCVAVKNFLLFSSKTAVRGIPFTLSTQEDVMVPV
TGSPSFFVGIDFDAQHSTVFYSDLSKDIIYKQKIDGTGKEVITANRLESV
ECLTFDWISRNLYWTDGGLKSVTVLRLADKSRRQIISNLNNPRSIVVHPT
AGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSASRLYW
VDAFFDKIEHSTLDGLDRKRLGHVDQMTHPFGLTVFKDNVFITDWRLGAI
IRVRKSDGGDMTVIRRGISSVMHVKAYDADLQTGSNYCSQTTHANGDCSH
FCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSLSFPCNNG
KCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFACVRGGQCIPGQWH
CDRQNDCLDGSDEQNCPTHATSSTCPSTSFTCDNHVCIPKDWVCDTDNDC
SDGSDEKNCQASGTCQPTQFRCPDHRCISPLYVCDGDKDCADGSDEAGCV
LNCTSAQFKCADGSSCINSRYRCDGVYDCRDNSDEAGCPTRPPGMCHLDE
FQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCSPTHFLCDNGNCI
YKAWICDGDNDCRDMSDEKDCPTQPFHDTGTRCNQLQFTCLNGHCINQDW
KCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYHYRCDYYNDCG
DNSDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNC
PPHTCPPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSN
EFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSV
3D structure
PDB8jxc Cryo-EM structures elucidate the multiligand receptor nature of megalin.
ChainA
Resolution3.7 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F741 R828 W844 W870 N872 H914 F556 R643 W659 W685 N687 H729
BS02 CA A Y200 D203 D205 D207 D213 E214 Y15 D18 D20 D22 D28 E29
BS03 CA A W239 D242 D244 D246 D252 E253 W54 D57 D59 D61 D67 E68
BS04 CA A K283 D286 V288 D290 D296 E297 K98 D101 V103 D105 D111 E112
BS05 CA A S575 D578 P601 T1131 S390 D393 P416 T946
BS06 CA A A888 D891 T913 A703 D706 T728
BS07 CA A F1042 D1045 V1047 D1049 D1055 E1056 F857 D860 V862 D864 D870 E871
BS08 CA A W1084 D1087 Q1089 D1091 D1097 E1098 W899 D902 Q904 D906 D912 E913
BS09 CA A W1127 D1130 D1132 D1134 D1140 E1141 W942 D945 D947 D949 D955 E956
BS10 CA A Y1167 D1170 D1172 D1174 D1180 E1181 Y982 D985 D987 D989 D995 E996
BS11 CA A Y1206 D1209 V1211 D1213 D1219 E1220 Y1021 D1024 V1026 D1028 D1034 E1035
BS12 CA A W1249 D1252 H1254 D1256 D1262 E1263 W1064 D1067 H1069 D1071 D1077 E1078
BS13 CA A W1289 D1292 D1294 D1296 D1302 E1303 W1104 D1107 D1109 D1111 D1117 E1118
BS14 CA A W2718 D2721 D2723 D2725 D2731 W1150 D1153 D1155 D1157 D1163
BS15 CA A Y2759 D2762 Y2764 D2766 D2772 E2773 Y1191 D1194 Y1196 D1198 D1204 E1205
BS16 CA A Y2799 C2801 N2802 I2804 N2806 D2814 E2815 Y1231 C1233 N1234 I1236 N1238 D1246 E1247
BS17 CA A F2841 D2844 D2846 D2848 D2854 E2855 F1273 D1276 D1278 D1280 D1286 E1287
BS18 CA A W2883 C2885 D2886 E2888 D2890 D2896 E2897 W1315 C1317 D1318 E1320 D1322 D1328 E1329
External links
PDB RCSB:8jxc, PDBe:8jxc, PDBj:8jxc
PDBsum8jxc
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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