Structure of PDB 8jxb Chain A

Receptor sequence

>8jxbA (length=244) Species: 10116 (Rattus norvegicus) [Search protein sequence]

DTGTRCNQLQFTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRST
AFTCGNGRCVPYHYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCI
PLSYVCNGINNCHDNDTSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDG
DNDCGDGSDENPIYCASHTCRSNEFQCLSPQRCIPSYWFCDGEADCADGS
DEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDE

3D structure

PDB

8jxb Cryo-EM structures elucidate the multiligand receptor nature of megalin.

Chain

Resolution

3.7 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	W2718 D2721 D2723 D2725 D2731 E2732	W23 D26 D28 D30 D36 E37
BS02	CA	A	Y2759 D2762 Y2764 D2766 D2772	Y64 D67 Y69 D71 D77
BS03	CA	A	Y2799 V2800 N2802 I2804 N2806 D2814 E2815	Y104 V105 N107 I109 N111 D119 E120
BS04	CA	A	F2841 D2844 D2846 N2847 D2848 D2854 E2855	F146 D149 D151 N152 D153 D159 E160
BS05	CA	A	W2883 D2886 E2888 D2890 D2896 E2897	W188 D191 E193 D195 D201 E202
BS06	CA	A	W2925 D2928 D2930 D2932 D2938 E2939	W230 D233 D235 D237 D243 E244

External links

PDB	RCSB:8jxb, PDBe:8jxb, PDBj:8jxb
PDBsum	8jxb
PubMed	38771880
UniProt	P98158\|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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