Structure of PDB 8jwi Chain A

Receptor sequence
>8jwiA (length=1164) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KISFFLPFKCLPAQHRKLLFISFVCAVLSGGTLPFFISVFGVILKNINPI
ILSLVSIGLVQFILSMISSYCMDVITSKILKTLKLEYLRSVFYQDGQFHD
NNPGSKLRSDLDFYLEQVSSGIGTKFITIFTYASSFLGLYIWSLIKNARL
TLCITCVFPLIYVCGVICNKKVKLNKKTSLLYNNNTMSIIEEALMGIRTV
ASYCGEKTILNKFNLSETFYSKYILKANFVEALHIGLINGLILVSYAFGF
WYGTRIIINSATNQGASVISILLGVLISMFMLTIILPNITEYMKALEATN
SLYEIINRKPLVENNDDGETLPNIKKIEFKNVRFHYDTRKDVEIYKDLSF
TLKEGKTYAFVGESGCGKSTILKLIERLYDPTEGDIIVNDSHNLKDINLK
WWRSKIGVVSQDPLLFSNSIKNNIKYSLYSLKDLEAMENYLEMKKEYQTI
KDSDVVDVSKKVLIHDFVSSLPDKYDTLVGSNASKLSGGQKQRISIARAI
MRNPKILILDQATSSLDNKSEYLVQKTINNLKGNENRITIIIAHRLSTIR
YANTIFVLSNRNEGSYIIEQGTHDSLMKNKNGIYHLMINNQKPNNLRIIY
KEIFSYKKDVTIIFFSILVAGGLYPVFALLYARYVSTLFDFANLEYNSNK
YSIYILLIAIAMFISETLKNYYNNKIGEKVEKTMKRRLFENILYQEMSFF
DQDKNTPGVLSAHINRDVHLLKTGLVNNIVIFSHFIMLFLVSMVMSFYFC
PIVAAVLTFIYFINMRVFAVRAFKDPSFLIQEAFYNMHTVINYGLEDYFC
NLIEKAIDYKNKGQKRRIIVNAALWGFSQSAQLFINSFAYWFGSFLIKRG
TILVDDFMKSLFTFIFTGSYAGKLMSLKGDSENAKLSFEKYYPLMIRKSN
IDVRDDGGIRINKNLIKGKVDIKDVNFRYISRPNVPIYKNLSFTCDSKKT
TAIVGETGSGKSTFMNLLLRFYDLNGEILLDDINICDYNLRDLRNLFSIV
SQEPMLFNMSIYENIKFGREDATLEDVKRVSKFAAIDEFIESLPNKYDTN
VGPYGKSLSGGQKQRIAIARALLREPKILLLDQATSSLDSNSEKLIEKTI
VDIKDKADKTIITIAHRIASIKRSDKIVVFNNPDRNGTFVQSHGTHDELL
SAQDGIYKKYVKLA
3D structure
PDB8jwi The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
ChainA
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.3.44: Transferred entry: 7.6.2.2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A Y387 S415 C417 G418 K419 S420 T421 Q462 S1313 G1315 Y336 S364 C366 G367 K368 S369 T370 Q411 S1059 G1061
BS02 ATP A K562 S564 Y1135 R1138 G1166 K1167 S1168 T1169 K485 S487 Y929 R932 G960 K961 S962 T963
BS03 MG A S1168 Q1256 S962 Q1002
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0020020 food vacuole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jwi, PDBe:8jwi, PDBj:8jwi
PDBsum8jwi
PubMed37527341
UniProtQ7K6A5

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