Structure of PDB 8jwf Chain A

Receptor sequence
>8jwfA (length=1204) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
SIKEEVEKELNKKSTAELFRKIKNEKISFFLPFKCLPAQHRKLLFISFVC
AVLSGGTLPFFISVFGVILKNMNLGDDINPIILSLVSIGLVQFILSMISS
YCMDVITSKILKTLKLEYLRSVFYQDGQFHDNNPGSKLRSDLDFYLEQVS
SGIGTKFITIFTYASSFLGLYIWSLIKNARLTLCITCVFPLIYVCGVICN
KKVKLNKKTSLLYNNNTMSIIEEALMGIRTVASYCGEKTILNKFNLSETF
YSKYILKANFVEALHIGLINGLILVSYAFGFWYGTRIIINSAFNGASVIS
ILLGVLISMFMLTIILPNITEYMKALEATNSLYEIINRKPLVENNDDGET
LPNIKKIEFKNVRFHYDTRKDVEIYKDLSFTLKEGKTYAFVGESGCGKST
ILKLIERLYDPTEGDIIVNDSHNLKDINLKWWRSKIGVVSQDPLLFSNSI
KNNIKYSLYSLKDLEAMENLEMKKEYQTIKDSDVVDVSKKVLIHDFVSSL
PDKYDTLVGSNASKLSGGQKQRISIARAIMRNPKILILDEATSSLDNKSE
YLVQKTINNLKGNENRITIIIAHRLSTIRYANTIFVLSNRNEGSYIIEQG
THDSLMKNKNGIYHLMINNQKAPNNLRIIYKEIFSYKKDVTIIFFSILVA
GGLYPVFALLYARYVSTLFDFANLEYNSNKYSIYILLIAIAMFISETLKN
YYNNKIGEKVEKTMKRRLFENILYQEMSFFDQDKNTPGVLSAHINRDVHL
LKTGLVNNIVIFSHFIMLFLVSMVMSFYFCPIVAAVLTFIYFINMRVFAV
RARLTKSKEIEKKEDPSFLIQEAFYNMHTVINYGLEDYFCNLIEKAIDYK
NKGQKRRIIVNAALWGFSQSAQLFINSFAYWFGSFLIKRGTILVDDFMKS
LFTFIFTGSYAGKLMSLKGDSENAKLSFEKYYPLMIRKSNIDVRDDGGIR
INKNLIKGKVDIKDVNFRYISRPNVPIYKNLSFTCDSKKTTAIVGETGSG
KSTFMNLLLRFYDLNGEILLDDINICDYNLRDLRNLFSIVSQEPMLFNMS
IYENIKFGREDATLEDVKRVSKFAAIDEFIESLPNKYDTNVGPYGKSLSG
GQKQRIAIARALLREPKILLLDEATSSLDSNSEKLIEKTIVDIKDKADKT
IITIAHRIASIKRSDKIVVFNNPDRNGTFVQSHGTHDELLSAQDGIYKKY
VKLA
3D structure
PDB8jwf The structure of Plasmodium falciparum multidrug resistance protein 1 reveals an N-terminal regulatory domain.
ChainA
Resolution3.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.3.44: Transferred entry: 7.6.2.2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YMZ A F331 Q1038 F310 Q872
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0020020 food vacuole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jwf, PDBe:8jwf, PDBj:8jwf
PDBsum8jwf
PubMed37527341
UniProtQ7K6A5

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