Structure of PDB 8jv6 Chain A

Receptor sequence
>8jv6A (length=316) Species: 7955 (Danio rerio) [Search protein sequence]
IAYVIGYVCVYNKGYQDTDTVLSSVTTKVKGIALTNTSELGERIWDVADY
IIPPQEDGSFFVLTNMIITTNQTQSKCAENPTPASTCTSHRDCKRGFNDA
RGDGVRTGRCVSYSASVKTCEVLSWCPLEKIVDPPNPPLLADAENFTVLI
KNNIRYPKFNFNKRNILPNINSSYLTHCVFSRKTDPDCPIFRLGDIVGEA
EEDFQIMAVRGGVMGVQIRWDCDLDMPQSWCVPRYTFRRLDNKDPDNNVA
PGYNFRFAKYYKNSDGTETRTLIKGYGIRFDVMVFGQAGKFNIIPTLLNI
GAGLALLGLVNVICDW
3D structure
PDB8jv6 Structural insights into the allosteric inhibition of P2X4 receptors.
ChainA
Resolution3.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P6E A R85 A90 D91 I94 P96 F299 R43 A48 D49 I52 P54 F257
Gene Ontology
Molecular Function
GO:0001614 purinergic nucleotide receptor activity
GO:0002135 CTP binding
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
GO:0005216 monoatomic ion channel activity
GO:0005524 ATP binding
GO:0015267 channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0017076 purine nucleotide binding
GO:0035381 ATP-gated ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0033198 response to ATP
GO:0034220 monoatomic ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0060079 excitatory postsynaptic potential
GO:0070588 calcium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0098794 postsynapse
GO:1902495 transmembrane transporter complex

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Cellular Component
External links
PDB RCSB:8jv6, PDBe:8jv6, PDBj:8jv6
PDBsum8jv6
PubMed37833294
UniProtF8W463|P2X4A_DANRE P2X purinoceptor 4a (Gene Name=p2rx4a)

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