Structure of PDB 8jua Chain A

Receptor sequence

>8juaA (length=390) Species: 1469403 (Streptomyces sp. ZJ306) [Search protein sequence]

LLTFPFASTGLEFPPVYHELYQQRLTKVRLPYGDDAYLAIRYADVKTVLS
DSRFSIVASLGQDQPRTRAGARVGNGLFSLDPPQHSRLRSVLGRDFTPRR
VEKLRERVRELTDQCLDRMEAAGSPADLVAHLAVPMPTAVVCEMMGVPEP
DHHLFWGWAETILSNDTTPDDLIRRYQEFTAYMGAMVEERRARPTDDMFG
MLVRACDEEGRITEIEMHALASDLLSAGFVSTAHQIANFTAMLLARPERL
QPLVDKPEQIPAAVEELMRHVPILSGFSFPRYATEDLEMSGVTVRRGEAV
IPVIAAANRDPDVYPDAGRLDLERNGLPHLGFGQGPHFCIGAHLARVELQ
VVLEALTERFPDLRFGIPENALKWKRGHFMNGLHELPVAW

3D structure

PDB

8jua A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates.

Chain

Resolution

2.00001 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	L95 F96 H103 R107 F114 A245 G246 S249 T250 S296 R299 G349 H355 C357 I358 G359	L77 F78 H85 R89 F96 A227 G228 S231 T232 S278 R281 G331 H337 C339 I340 G341
BS02	F7Z	A	R86 R90 V91 I180 D241 S244 A245 S249 I291 L292 M398	R68 R72 V73 I162 D223 S226 A227 S231 I273 L274 M380

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

View graph for
Molecular Function

External links

PDB	RCSB:8jua, PDBe:8jua, PDBj:8jua
PDBsum	8jua
PubMed	37917570
UniProt	A0A0B4ZV78

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