Structure of PDB 8jta Chain A

Receptor sequence
>8jtaA (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
SRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSKDLLNENVQVGLLFASK
ATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIA
RSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPF
GSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTL
LKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPAS
ISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPN
FGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPS
AGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPP
3D structure
PDB8jta Transport and inhibition mechanisms of human VMAT2.
ChainA
Resolution3.36 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YHL A L37 F135 R189 E312 Y341 Y433 L20 F47 R101 E224 Y253 Y345
Gene Ontology
Molecular Function
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jta, PDBe:8jta, PDBj:8jta
PDBsum8jta
PubMed38081299
UniProtQ05940|VMAT2_HUMAN Synaptic vesicular amine transporter (Gene Name=SLC18A2)

[Back to BioLiP]