Structure of PDB 8jsw Chain A

Receptor sequence
>8jswA (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
SRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHENVQVGLLFASKAT
VQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARS
LQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLK
DPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASIS
YLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFG
VGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAG
GAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPP
3D structure
PDB8jsw Transport and inhibition mechanisms of human VMAT2.
ChainA
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRO A E312 Y341 E222 Y251
Gene Ontology
Molecular Function
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jsw, PDBe:8jsw, PDBj:8jsw
PDBsum8jsw
PubMed38081299
UniProtQ05940|VMAT2_HUMAN Synaptic vesicular amine transporter (Gene Name=SLC18A2)

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