Structure of PDB 8jqr Chain A

Receptor sequence
>8jqrA (length=531) Species: 9606 (Homo sapiens) [Search protein sequence]
SYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFY
FGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVAD
NTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKI
GVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVL
EVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMI
IFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFL
QRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLAL
GWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVT
LIEDSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTY
ILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFR
SGKLLQVGYTPDGKDDYRWCFRVDEVNWTTW
3D structure
PDB8jqr Structural basis of TRPV1 inhibition by SAF312 and cholesterol
ChainA
Resolution2.75 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EZI A S512 L515 T550 N551 L553 T556 R557 G563 A566 V567 W698 Q701 S315 L318 T353 N354 L356 T359 R360 G366 A369 V370 W476 Q479
BS02 CLR A F507 V508 Y511 A546 L547 T550 E570 I573 F310 V311 Y314 A349 L350 T353 E373 I376
External links
PDB RCSB:8jqr, PDBe:8jqr, PDBj:8jqr
PDBsum8jqr
PubMed39107321
UniProtQ8NER1|TRPV1_HUMAN Transient receptor potential cation channel subfamily V member 1 (Gene Name=TRPV1)

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