Structure of PDB 8jpr Chain A

Receptor sequence
>8jprA (length=730) Species: 9606 (Homo sapiens) [Search protein sequence]
KDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVG
LFVDFFVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLAS
LLVLIEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGL
FVEKEGPMIHSGSVVGAGLPQFYFRSDRDKRDFVSAGAAAGVAAAFGAPI
GGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQL
PGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRL
AKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSIKTF
FCPNDTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACW
TYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYSGTFALIGAAA
FLGGVVRMTISLTVILIESTNEITCGLPIMVTLMVAKWTGDFFNKGIYDI
HVGLRGVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTT
VHHAFPVVTENRGNQLISNNIKFKKSSILTRAGEQRKRSQSTMEERFRPL
TFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHD
LDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVN
AVGEIVGIITRHNLTYEFLQARLRQHYQTI
3D structure
PDB8jpr Molecular basis of ClC-6 function and its impairment in human disease
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A S50 E606 H630 H631 R833 H834 I847 T849 H851 N852 S5 E528 H552 H553 R694 H695 I708 T710 H712 N713
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0005524 ATP binding
GO:0015108 chloride transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0006884 cell volume homeostasis
GO:0007165 signal transduction
GO:0009612 response to mechanical stimulus
GO:0034220 monoatomic ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jpr, PDBe:8jpr, PDBj:8jpr
PDBsum8jpr
PubMed
UniProtP51797|CLCN6_HUMAN H(+)/Cl(-) exchange transporter 6 (Gene Name=CLCN6)

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