Structure of PDB 8jp0 Chain A

Receptor sequence
>8jp0A (length=719) Species: 9606 (Homo sapiens) [Search protein sequence]
GSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFM
SSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEIL
LSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKH
LRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAW
VADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPPVSKIFFEQGTYQCLEN
CGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDT
QKEIRVGIIDDDIFEEDENFLVHLSNVKVSLACLGSPSTATVTIFDDDHA
GIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGED
FEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK
SKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVV
GTNSWREQFIEAITVSASCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACF
IVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASK
VAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSP
GTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLL
WLLYIFFSSLEAYCHIKGF
3D structure
PDB8jp0 Mechanistic insight into allosteric inhibition of human sodium-calciumexchanger NCX1 by XIP and SEA0400
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EKY A L137 T138 H200 C245 E279 D828 G832 G836 L87 T88 H150 C195 E229 D610 G614 G618
Gene Ontology
Molecular Function
GO:0005432 calcium:sodium antiporter activity
Biological Process
GO:0006816 calcium ion transport
GO:0007154 cell communication
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jp0, PDBe:8jp0, PDBj:8jp0
PDBsum8jp0
PubMed38177313
UniProtP32418|NAC1_HUMAN Sodium/calcium exchanger 1 (Gene Name=SLC8A1)

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