Structure of PDB 8jot Chain A

Receptor sequence
>8jotA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
KPKYQVRWKIIESYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVV
EATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV
NLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSGRPLELRDLLH
FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDS
NYIVKGARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPG
ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQITS
FLQEQA
3D structure
PDB8jot Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
ChainA
Resolution1.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UKI A L588 A614 Y665 C666 T667 Y668 G669 D670 L785 F797 A800 L41 A67 Y118 C119 T120 Y121 G122 D123 L178 F190 A193
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8jot, PDBe:8jot, PDBj:8jot
PDBsum8jot
PubMed38172256
UniProtP07333|CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (Gene Name=CSF1R)

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