Structure of PDB 8jnk Chain A

Receptor sequence
>8jnkA (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
RVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLSQDVPWKQRT
GIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENT
GHTFNSLLCNLYRNEKDSVDWHSDDCPSLGRSPIIASLSFGATRTFEMRK
KPPPEVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRT
VYP
3D structure
PDB8jnk The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation
ChainA
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
1.14.11.54: mRNA N(1)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R122 E123 I125 Y127 R131 Y141 Y143 S144 V188 D189 H191 D193 C195 K261 Y263 R53 E54 I56 Y58 R62 Y72 Y74 S75 V119 D120 H122 D124 C126 K185 Y187
BS02 MN A H191 D193 H257 H122 D124 H181
Gene Ontology
Molecular Function
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:8jnk, PDBe:8jnk, PDBj:8jnk
PDBsum8jnk
PubMed38158383
UniProtQ96Q83|ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Gene Name=ALKBH3)

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