Structure of PDB 8jni Chain A

Receptor sequence
>8jniA (length=497) Species: 9606 (Homo sapiens) [Search protein sequence]
DPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSP
AITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLL
VFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRF
TQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCPRGQPNTALLSLVLMAG
TFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQ
KLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFM
ETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVR
SVTHANALTVMVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLY
MGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCL
ALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEA
3D structure
PDB8jni Structural and functional insights into the lipid regulation of human anion exchanger 2.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PT5 A L1143 P1145 K1147 H1148 L419 P421 K423 H424
BS02 PT5 A P928 G929 R932 P218 G219 R222
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008509 monoatomic anion transmembrane transporter activity
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0019899 enzyme binding
GO:0022857 transmembrane transporter activity
GO:0140900 chloride:bicarbonate antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006820 monoatomic anion transport
GO:0007283 spermatogenesis
GO:0015698 inorganic anion transport
GO:0015701 bicarbonate transport
GO:0030316 osteoclast differentiation
GO:0032956 regulation of actin cytoskeleton organization
GO:0034220 monoatomic ion transmembrane transport
GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045124 regulation of bone resorption
GO:0048565 digestive tract development
GO:0051453 regulation of intracellular pH
GO:0055085 transmembrane transport
GO:0070175 positive regulation of enamel mineralization
GO:0097186 amelogenesis
GO:0098656 monoatomic anion transmembrane transport
GO:0098660 inorganic ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:2000565 negative regulation of CD8-positive, alpha-beta T cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jni, PDBe:8jni, PDBj:8jni
PDBsum8jni
PubMed38272905
UniProtP04920|B3A2_HUMAN Anion exchange protein 2 (Gene Name=SLC4A2)

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